There is some good research on this!
We’ve done quite a bit of analysis, there’s about 800 published studies (see the end of the post) on how CBD is absorbed and what happens to if after it gets into the body.
There are a lot of recommendations out there about dosing, but we don’t have the mountain of research required to pinpoint the exact amount that is beneficial for the general public. Any dosing recommendation is just that- a recommendation.
To talk about how much you should be taking, we have to examine what we know about absorption and the effectiveness of the amounts that have been studied to date.
LET’S LOOK AT HOW CBD CAN BE ABSORBED:
The supposed highest rate of absorption has not been studied in humans: suppository. Most people do not want much of anything going up there, much less an oil tincture.
But… (pun intended), in theory it does work! You’re bypassing the liver and therefore more CBD is absorbed into the blood before the liver get’s its filters on it and breaks it down. The result is more bang for your buck, as you’ll get much more of the dose put to use.
The next highest absorption rate would be via inhalation
Vaping CBD allows the molecule to be carried into lung tissue via very tiny vapor particles which, when delivered to your alveoli (tiny air sacs in the lungs), allow for the CBD to seep into the blood stream. The surface area is the key to this delivery system. You get so much of the CBD molecule spread out over these tiny air sacs with microscopic-thin walls that are able to permeate through the tissue right into the blood stream that’s already in place to pick up and drop off oxygen. CBD just hitches a ride.
Disclaimer- Omnia doesn’t sell CBD vape juice for a great reason. We won’t get behind something we don’t believe in 100%. And we don’t believe the propellants and chemicals in vape cartridges are healthy. There needs to be more research into the effects of these chemicals before we will put our name on a vape-able CBD.
Sublingual translates literally to “under the tongue”. The floor of your mouth under your tongue has a thickness of 100 micrometers (slightly thicker than notebook paper) and is rich with blood supply. The sublingual glands are supplied with blood flow from the lingual artery which comes off of the main artery feeding your brain, the carotid arteries. Research has shown sublingual administration of medication allows fast access to the blood flow around your brain. By absorbing under your tongue, you don’t allow the liver to break down the CBD before it gets placed in your bloodstream, allowing for more effect from the dose you take. Otherwise you’d have to take a much higher amount to achieve the same results as sublingual. There are a few things that affect sublingual absorption in medications, and it’s recommended that you don’t smoke before any kind of sublingual administration as it reduces blood flow and therefore reduces absorption.
We’ve provided a step-by-step guide on how to take CBD here
This is definitely the most convenient way to take CBD, but it is not the most effective. Oral CBD is most commonly placed in capsules, and once in the stomach, is brought into hepatic circulation which is the liver’s main blood flow. The liver metabolizes and partially breaks down the CBD molecule in what’s called the first passeffect. Research found out that taking CBD with fatty acids or fatty foods will help bypass the first pass effect and you can absorb more into your blood stream where you want it.
One of the skin’s primary jobs is to keep stuff out. It needs to be waterproof and to act as a barrier to the outside world, so it naturally has low absorption. The good thing about using CBD on the skin is that it will stay in the local area where you apply it. If you’re trying to relieve an ache, pain, or injury in the area, then a CBD salve or lotion is great for local use. It will not enter your bloodstream, but it will penetrate into the tissues, and it can potentially provide relief.
WHAT’S THE BEST ROUTE FOR YOU?
See how you feel with taking CBD in any of the above ways. The higher absorption routes are recommended for treating system-wide problems like sleep or anxiety. But an ache or pain can be treated with transdermal application. It’s up to you!
HOW MUCH SHOULD YOU TAKE?
Every study out there uses a different dose. Some are weight based, some are spread throughout the day, and some have cycles on and off every few days.
All pharmacokinetic studies in humans had a few common conclusions: the peak effects of CBD are about 4 hours, and how much CBD is absorbed will depend on how much you take. Seems obvious, right?
Take these 4 things into consideration:
- How much CBD one can absorb varies drastically from person to person based on a large number of factors
- Oral and sublingual administration showed a max concentration in the blood can take several days
- Most studies show absolutely no negative side effects from CBD use. Some show side effects of diarrhea and dizziness.
- CBD can interact with your medication. This is especially true with blood thinners, so consult with your physician about taking CBD with other medications
The point being, you can be extremely confident that increasing your dose will be safe.
It’s all about how you feel.
If you’re not getting the results you want after about a week or so of consistent use, don’t be afraid to up your dose!
Thanks for reading! If you have any questions, leave a comment below and don’t forget to like and share this article with a friend that would benefit from seeing this!