Can antihistamines help with anxiety?

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    Temporarily, yes. That’s because the antihistamine is blocking the production of histamine, which prevents the fight or flight sympathetic response that gives you anxiety. But what also happens when you take antihistamines is you block your body’s production of an important enzyme called Diamine oxidase (DAO). DAO is largely produced by the kidneys and in the gut and is the primary enzyme in degrading histamine. So when you take the antihistamine you are blocking histamine and will feel temporary relief from anxiety but once it wears off the symptoms will come back. You can keep taking the antihistamine but as soon as you come off the fight or flight will come back twice as strong. My preferred way of processing histamine in a healthy way is by taking DAO in supplement form, which can be found online. Histaminum hydrocloridium is another natural way to bring down histamine levels without blocking dao, it’s a cheap homeopathic. Also avoid alcohol because it blocks DAO as well. Following food combining rules can also reduce histamine so I follow those rules daily.

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    Yes.

    Hydroxyzine, otherwise know as vistartil, is thought to be the most effective. It helps with the blocking of the histamine receptors. The research suggests it inhibits a seritonin receptor as well.

    It is best for short term use, although has less side effects than benzodiazepines, which can be highly addictive and stop the formation of memories, thereby making the effectiveness of psychotherapy less productive.

    Also, benzodiazepines can be dangerous, even fatal, when mixed with alcohol or apiates.

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    I only know of one antihistamine that is used to treat Anxiety, Hydroxyzine. Along with its H1 receptor Inverse Agonist properties, I have seen some sources mention that it effects Serotonin levels or receptors, but I will not say with certainty that that is true. I was prescribed this medication for anxiety and found it ineffective, it made me sleepy but didn’t reduce anxiety. However, for others it may help with anxiety.

    As you see most favor Hydroxyzine, Wiki states – Hydroxyzine has shown to be as effective as the benzodiazepine drug bromazepam in the treatment of generalized anxiety disorder.

    The one big problem I have with this drug is that is can cause heart problems. Fast or irregular beats may occur.

    Read for yourself what wiki says – Hydroxyzine – Wikipedia Look at the side effects as they are/can be quite nasty.

    I take three different ones, mainly to control hay fever, allergic reactions and sinusitis, as I have very bad sinuses and was refused surgery, so I was left with drugs.

    Obviously the best way to treat anxiety (In My Opinion) is to talk to your doctor or a psychologist, as I always believe in finding the root cause of any mental health problem, before recommending any drug.

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    Anectdotally, from my observations & experiences, (certain) antihistamines can help someone suffering from anxiety — if that person is “naive” to stronger medicines. Diphenhydramine and chlorpheniramine come to mind. These days, lots of doctors prescribe hydroxyzine for anxiety (because its non-addicting and it triggers drowsiness), but I don’t think its that good.

    What? Thats the craziest thing I’ve heard. I have suffered with anxiety my whole life and I know many others who have as well and no one has ever mentioned anything about antihistamines helping with anxiety. They might make you drowsy, but that’s not helping with anxiety. Do some research online. Ask a doctor.

    Best of luck to you.

    Besides minor tranquilizers such as benzodiazepines, the short term anti anxiety drugs have very weak evidence of working.

    Hydroxizine is sometimes used but the response is minimal, and it will cause drowsyness like Benadryl. So in theory, just this one can. In practice….not really.

    They actually work when used for allergies by calming the brain so you’re not as sensitive to whatever triggered the allergy. I’ve never taken them myself for anxiety but I do know certain types can be used for it. Not sure how effective they are though.

    I would say at least to some degree, though the only explanation I can think of is that antihistamines are also somewhat sedating. This means that the body relaxes to some degree, and as a result, can ease some anxiety.

    A little bit. Not that significantly though.

    Some of them could actually make it worse. It kind of depends on the type of anxiety you have. But generally, they won’t do much.

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